First Example of Lewis Acid Catalyzed 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Formation

Brian T. Gregg; William G. Earley; Kathryn C. Golden; John F. Quinn; Dana A. Razzano; W. Martin Rennells

doi:10.1055/s-2006-950342

PAPER

First Example of Lewis Acid Catalyzed 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Formation

Brian T. Gregg*, William G. Earley, Kathryn C. Golden, John F. Quinn, Dana A. Razzano, W. Martin Rennells
Albany Molecular Research, Inc., 21 Corporate Circle, PO Box 15098, Albany, NY 12212-5098, USA
Fax: +1(518)8674381; e-Mail: brian@albmolecular.com;

Abstract

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Abstract

A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) triflate shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter reaction times, higher conversion, and better purity profiles as compared to the traditional uncatalyzed reactions.

Key words

Lewis acids - catalysis - heterocycles - indium - condensation

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References

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